WebJul 27, 2024 · Exposure of mononuclear phagocytes to β-glucan, a naturally occurring polysaccharide, contributes to the induction of innate immune memory, which is associated with long-term epigenetic, metabolic, and functional reprogramming. ... We observed a comparable downregulatory effect of β-glucan–induced monocyte/macrophage … WebDDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage.
Anti-inflammatory effect of IL-10 mediated by metabolic …
WebMay 5, 2024 · To assess the role of DDIT4 in macrophages, we generated BMDMs from Ddit4 –/– mice and stimulated them with LPS. Cells lacking DDIT4 had prolonged … Webnovel targets of macrophage reprogram-ming to achieve macrophage defender roles directly at the DNA level, rather than by targeting cell surface or cyto-plasmic compartments (Figure 1B). Nu-clear targeting offers a unique approach to maximize activation of gene expression programs required for multiple macrophage defender activities. freshman index uga
DDIT4 contributes to macrophage reprogramming Nature Reviews
WebSep 2, 2024 · The macrophages in the core seemingly contribute more to the overall viability of the tumor via their expression of VEGFA and HIF1A, ... IL-1β, a proinflammatory cytokine, is a potential target for macrophage reprogramming because it impacts CSF1/CSF1R signaling. In early tumor progression models using 4T1 cells in Balb/c … WebMay 5, 2024 · The authors identified the expression of DNA-damage-inducible transcript 4 protein (DDIT4) in a STAT3-dependent manner early after LPS treatment in … WebAug 27, 2024 · Hypoxia has been shown to promote protumoral activity of TAMs by at least two mechanisms: (I) inducing an iron donor phenotype in TAMs and increased … fate william tell