WebHIF-1α subsequently translocates to the nucleus, where it dimerizes with HIF-1β , the constitutively expressed HIF-1 subunit, forming the transcription complex HIF-1 (5,6). In … Web3 de nov. de 2024 · It is worth noting that HIF-1α must form a heterodimer with HIF-1β before exerting its biological function . HIF-1β is stably expressed in cells and maintains the stability of HIF-1 (21,22). The structures included in HIF-1α and HIF-1β are basic-helix-loop-helix and PER-ARNT-SIM domain, which promote DNA binding and dimerization (9,23).
Hypoxia Inducible Factor 1 - an overview ScienceDirect Topics
WebThe ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) … WebHypoxia-inducible factor. Hypoxia-inducible factors ( HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1] [2] … shoes wirral
HIF-1α is a negative regulator of interferon regulatory factors
http://jms.qdu.edu.cn/Upload/html/59011.htm WebHIF-1α在低氧(氧浓度<5%)等条件下稳定性增加,从而在细胞内蓄积并转位到细胞核内与HIF-1β形成异二聚体;然后募集 HIF辅激活复合物成分(如p300),进而与目标基因启动区的顺式低氧反应元件(cis-acting hypoxia responsive elements,HREs)结合,从而启动靶基因的 … Web11 de mai. de 2024 · BCG is widely used for cancer treatment, where macrophages play an important role. However, the mechanism of BCG affecting macrophages remains poorly understood. In this study, we used BCG to stimulate myeloid-derived macrophages lacking HIF-1α, the levels of TNF-α, IL-1β, CD86 of macrophages and their effects on the growth … shoes wisely