WebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4'-diisothiocyanatostilbene-2,2' … Web20. aug 2024 · MitoNEET is a mitochondrial outer membrane protein that hosts a redox active [2Fe-2S] cluster in the C-terminal cytosolic domain. Increasing evidence has shown that mitoNEET has an essential role in regulating energy metabolism in human cells. Previously, we reported that the [2Fe-2S] clusters in mitoNEET can be reduced by the …
Purification of VDAC1 from Rat Liver Mitochondria - ResearchGate
WebThis work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and … WebThe Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In … ckfn
The Single Residue K12 Governs the Exceptional Voltage …
WebIsoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells (2024) … Web1. nov 2024 · MitoNEET is a redox active [2Fe–2S] cluster-containing protein which has been shown to regulate the oxidative capacity of mitochondria and cellular iron homeostasis . ... Redox-dependent gating of VDAC by mitoNEET. Proc. Natl. Acad. Sci. U. S. A., 116 (40) (2024), pp. 19924-19929. WebRedox-dependent gating of VDAC by mitoNEET. - CORE Reader do wind turbines need planning permission