Top2a gene

Author: iafs

August undefined, 2024

Web28. feb 2024 · TOP2A gene expression in esophageal cancer tissues was higher than para-cancer tissues and was closely related to the degree of infiltration, lymph node metastasis, differentiation, and the clinical … WebMenendez et al., 2006, DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes., Int. J. Mol. Med. Jiménez-Alonso S et al., 2008, Design and synthesis of a novel series of ...

TOP2A Gene Target - PubChem

WebGlioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes. J. Ladha , S. Donakonda , +12 authors … Web19. feb 2024 · Our data suggest that sex-specific gene expression in glioma-activated microglia may be relevant to the incidence and outcomes of glioma patients. ... Tuba1b, Cdk1, and Top2a), which is consistent ... happy 40th birthday image

DNA topoisomerase 1 and 2A function as oncogenes in liver …

Web10. apr 2024 · According to the results of GeneMANIA and STRING, correlation curves of six co-expressed genes (MKI67, TOP2A, BUB1, NDC80, CDC20 and FOXM1) displayed significant positive correlations with CENPF expression. As previously described, these genes are involved in cell cycle regulation [20,24,27,54,55,56]. It is noteworthy that TOP2A, … http://www.biodragon.cn/cgkt/110956.html Web1. máj 2005 · Javier A. Menendez, Luciano Vellon, Eva Horak, Ruth Lupu; DNA Topoisomerase IIα (TOP2A) inhibitors doxorubicin and etopoxide (VP-16) up-regulate … chainsaw man nuke devil

The TOP2A gene and its putative association with human ageing

Gene‐neuroimaging brain model decodes neuropathological …

WebTOP2A gene amplification and variables that were statistically significant associated with response in the univariate analysis were further evaluated in a multivariate analysis using … Web2. nov 2024 · TOP2A is essential for cell division, is highly expressed during mitosis, and is required for mitotic chromosome condensation and segregation ( 13 – 16 ). Genetic … chainsaw man north koreaWeb10. dec 2024 · TOP2A is a direct target gene for miR-144-3p, and TOP2A promotes the proliferation and migration of glioma cells. Overexpression of miR-144-3p suppresses the growth of glioma xenografts in nude mice. These data suggest that miR-144-3p is likely to inhibit proliferation by targeting TOP2A in HCMV-positive glioblastoma. 2. Results chainsaw man ocinek 4 cda

"Web7. dec 2024 · We identified 89 disease-driving genes, including some notable previously identified AD genetic determinants: APPB2, TOP2A, CLU, BACE1 and CD44. The biological factors causally modulated by each gene, and factor alterations resulting from the modulation were also reported; e.g., our model reveals that APPB2 gene modulates beta … " - Top2a gene

Top2a gene

Web28. dec 2024 · The sequence of 1 of the TOP2A cDNAs is identical to that of an internal fragment of the TOP2 cDNA isolated by Tsai-Pflugfelder et al. (1988). Southern blot … WebSequence variants and/or copy number variants (deletions/duplications) within the TOP2A gene will be detected with >99% sensitivity. Variants classified as unknown significance …

Did you know?

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products o… Web14. dec 2011 · Gene expression databases. Bgee. ENSMUSG00000020914 Expressed in undifferentiated genital tubercle and 223 other tissues; Genevisible. Q01320 MM; …

Web8. júl 2009 · TOP2A gene amplification was present in 14 (16%) and HER2 gene amplification in 38 (45%) of the primary tumours. Two of the 14 cases with TOP2A … Web21. mar 2024 · Entrez Gene Summary for ABTB1 Gene. This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor.

Web13. nov 2024 · In the current study, the eight hub genes selected by cytohubba were overexpressed in SCLC tissues compared to paired adjacent non-cancerous tissues. Lastly, seven of those hub genes, namely CDC20, TOP2A, BUBI, BUBIB, UBE2C, CCNA2 and MAD2L1 (all P-values <0.05), were closely related to the cell cycle pathway. Additionally, the mRNA … WebTopoisomerases are a family of proteins that alter DNA topology to accommodate for the stresses imparted by processes such as transcription, replication, and mitotic …

Web23. nov 2024 · The TOP2a gene controls a network of genes that contribute to ASD. Drugs that suppress TOP2a during development can turn on a cluster of other genes that disrupt brain development and increase autism risks. Alterations to the TOP2a gene may be responsible for the social behavioral difficulties associated with ASD.

WebPharmacological inhibition of TOP2A and KDM1A activity upregulates the expression of BAZ2A-repressed genes implicated in PCa that are regulated by a class of inactive enhancers bound by BAZ2A. Our findings indicate that RNA-mediated interactions between BAZ2A and TOP2A and KDM1A regulate gene expression in PCa and may prove to be … happy 40th birthday images svgWeb21. aug 2024 · For TOP2A, 2,485 genes were co-expressed, with 2,083 positively associated and 402 negatively associated genes. Examination of the intersection between the genes co-expressed with TOP1 and with TOP2A revealed 1,209 overlapping genes, which were selected for further analysis. The top 10 GO terms are displayed in Fig. 14. The co … chainsaw man odc 10 plWebtop2a ID ZDB-GENE-030131-2453 Name DNA topoisomerase II alpha Symbol top2a Nomenclature History Previous Names. fc08c07; wu:fc08c07; Type protein_coding_gene … happy 40th birthday images women